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Centre for Bio-analytical Research Leuven (CBRL)

The Centre for Bio-analytical Research Leuven assembles the analytical expertise within the Department of Pharmaceutical and Pharmacological Sciences related to drug determination in biological matrices. The main goal of this consortium is to develop novel analytical methodologies and to support pharmacokinetic, biopharmaceutical and toxicological studies within the framework of clinical studies. Therapeutic drug monitoring is not considered as a core activity of CBRL. The following laboratories are involved in CBRL:

The analytical armamentarium of CBRL includes:


  • LC-UV
  • LC-MS/MS
  • LC-MS
  • LC-PED
  • LC-fluorescence



  • nano-LC
  • CE-UV
  • CE-fluorescence
  • CE-C4D
  • GC-FID
  • GC-MS
  • GC-MS/MS


For more information about our activities: info@cbrl.be

Typical studies which illustrate the targeted collaboration are summarized below:

  • Walravens, J., Brouwers, J., Spriet, I., Tack, J., Annaert, P., Augustijns, P. (2011). Effect of pH and comedication on gastrointestinal absorption of posaconazole: monitoring of intraluminal and plasma drug concentrations. Clinical Pharmacokinetics, 50 (11), 726-734.

  • Bevernage, J., Brouwers, J., Clarysse, S., Vertzoni, M., Annaert, P., Tack, J., Augustijns, P. (2010). Drug supersaturation in simulated and human intestinal fluids representing different nutritional states. Journal of Pharmaceutical Sciences, 99 (11), 4525-4534.

  • Tayman, C., El-Attug, M., Adams, E., Van Schepdael, A., Debeer, A., Allegaert, K., Smits, A. (2011). Quantification of amikacin in bronchial epithelial lining fluid in neonates. Antimicrobial Agents and Chemotherapy, 55 (9), 3990-3993.

  • Verplaetse, R., Tytgat, J. (2010). Development and validation of a sensitive ultra performance liquid chromatography tandem mass spectrometry method for the analysis of fentanyl and its major metabolite norfentanyl in urine and whole blood in forensic context. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 878 (22), 1987-1996.

  • Meyer-Monath, M., Chatellier, C., Cabooter, D., Rouget, F., Morel, I., Lestremau, F. (2015). Development of liquid chromatography methods coupled to mass spectrometry for the analysis of substances with a wide variety of polarity in meconium. Talanta, 138, 231-9.